UPDATED: The main quest is finished. What can I say:
1. Graphics. Comparing them to Skyrim and complaining about system requirements is a BS and I call it. The game looks much better and its options can be easily tweaked to run smoothly and look gorgeous on my 5 years-old LAPTOP with nVidia 555m. If you have even worse than that - it's only your fault. The only minus here is to colorful sights, unlike in previous Fallout games. But maybe I just get used to Fallout 3 and New Vegas filters :) Though the music helps to create the needed atmosphere.
2. Bugs. Well, there are some. But no one is gamebreaking and overall the game is much more stable than ANY Bethesda game before it (at least staring with Fallout 3). During my 25 hours gameplay I had ONE crash-to-desktop. There is nothing to compare with the latest Witcher, which was in fact worse than Unity talking about bugs and optimization, but somehow people ignored that.
3. The world isn't that big, but there is much to do, I also like the main plot very much, partly because I was waiting for something with "androids" for a long time :) The only minus (a BIG one) for me is that (again, unlike in recent previous Bethesda games) we are given a character with strongly pre-defined story. Not like Witcher (thanks god), but still, and you can't even choose anything except gender. I'm not interesting in having some stupid son an "saving" him, at all. But I STILL has some hope about that. UPDATED. There is no hope. And this is just one HUGE minus for me. The newest Bethesda games always provided the strong role-playing where YOU define your character. But now it feels almost if I play Geralt - the character's story is STRONGLY pre-defined and it actually influences the whole game and plot. Disappointed.
4. I have no complains about gameplay mechanics and RPG system. They work, so it's enough for me. I was skeptical about new crafting (I mean building of settlements), but in fact I liked it!
There are also many little nuances that made experience even greater for me - voiced main character, interesting companions and NPCs that looks very alive (for example, if you hold too long the dialogue, they will ask you if you want to continue talking from time to time), animated quest narrations. Well-known (black) humor of Fallout games is also there. UPDATED: oh, and of course I love to see many of the mods' ideas implemented in the game. I won't spoil the names, but while playing and seeing one or another "new" element I can even recall a name of the mod or modder that had the particular idea in previous games!

RPG OTY. Maybe would give it a 9, but it seems some fanboys of either Witcher or older Fallout games are being unfair. Oh, well. 10 it is. UPDATED. No, it IS worth 10, absolutely. Despite the minus I've mentioned earlier. It is a rare game where I had to think so deeply and carefully about my choices. I even had to turn off my game several times to think more. And the "endings" (though we know there is no actual "end")... I can't stop rethinking after them. That's what I call hard choices! Good job!