Rákkutattás - United Devices
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Tomcat #304 Az oxfordi egyetem kémia részlegének weblapján ez áll:
Phase 2 of the Project
As of 1 July 2002 we have moved into Phase 2 of the Screensaver Project. In Phase 1, using the THINK software, some 3.5 billion drug-like molecules, mostly as yet unsynthesised, have been tested against 12 proteins which are known as suitable targets for anti-cancer drugs. Each single molecule has been tested a multiple of times to ensure a complete coverage and to give some quality reassurance. Those molecules predicted to bind better than a somewhat arbitrary threshold have been termed 'hits', with the most promising having negative binding energies on our scale.
A major goal of Phase 2 using the LigandFit software is to refine these data to produce a more manageable list of promising candidates for synthesis and testing which will of course be costly and require experimental collaborators including some from industry.